Lay the tortillas flat on a clean work surface.
Spread about 1 tablespoon of pizza sauce over each tortilla, leaving a small border around the edges.
Arrange 4 slices of pepperoni on each tortilla.
Sprinkle mozzarella cheese evenly over the pepperoni.
Roll each tortilla tightly into a burrito shape, folding in the sides as you roll.
Brush the outside of each roll-up with melted butter.
Mix the Parmesan cheese, Italian seasoning, garlic powder, onion powder, and crushed red pepper flakes together, then sprinkle over the roll-ups.
Preheat the air fryer to 380°F (193°C).
Place the roll-ups seam-side down in the air fryer basket, leaving space between them.
Air fry for 8 to 10 minutes, turning halfway through, until golden brown and crispy.
Let cool for 2 to 3 minutes before slicing or serving whole with warm pizza sauce.